Search results for "GRAFT LOSS"

showing 2 items of 2 documents

Hepatitis C virus intrinsic molecular determinants may contribute to the development of cholestatic hepatitis after liver transplantation

2018

Cholestatic hepatitis C (CHC) is a severe form of hepatitis C virus (HCV) infection recurrence that leads to high graft loss rates early after liver transplantation (LT). To investigate the pathogenic mechanisms of CHC, we analysed HCV quasispecies in CHC patients compared to a control group (mild hepatitis C recurrence) by deep pyrosequencing. At the time of LT, NS5B quasispecies complexity was similar between the two groups but, after LT, it decreased more sharply in CHC patients than in the control group. Interestingly, the major variant before LT propagated efficiently and remained as the dominant sequence after LT in 62 % of CHC patients versus 11 % of controls (P=0.031). Sequence anal…

0301 basic medicineMalemedicine.medical_specialtyGenotypeDeep sequencingSequence analysismedicine.medical_treatmentHepatitis C virus030106 microbiologyViral quasispeciesHepacivirusLiver transplantationBiologyViral Nonstructural ProteinsGraft lossmedicine.disease_causeGastroenterology03 medical and health scienceschemistry.chemical_compoundVirologyInternal medicinemedicineHumansNS5BAgedLiver transplantationHepatitis C virusHigh-Throughput Nucleotide SequencingHepatitis CHepatitis C ChronicMiddle Agedmedicine.diseaseVirologyCholestatic hepatitis CLiver TransplantationJaundice ObstructiveQuasispecies030104 developmental biologychemistryCholestatic hepatitisFemale
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Repeated kidney re-transplantation—the Eurotransplant experience: a retrospective multicenter outcome analysis

2020

Transplant international (2020). doi:10.1111/tri.13569

re-transplantationOutcome analysis030230 surgeryKidneyALLOCATION0302 clinical medicine3RDfourthKidney transplantationKidneychildGraft SurvivalConfoundinglossSUCCESSrepeatedGRAFT LOSSCOMPETING RISKSTissue Donorsddc:Treatment Outcomesurgical procedures operativemedicine.anatomical_structure030211 gastroenterology & hepatologyOutcome dataLife Sciences & Biomedicinemedicine.medical_specialtykidneyTissue and Organ ProcurementRe transplantation610survival1ST03 medical and health sciencesmedicineHumansddc:6102NDRetrospective StudiesDeceased donorTransplantationScience & Technologybusiness.industrymedicine.diseaseKidney TransplantationSurgeryTransplantationRECIPIENTSgraftSurgeryHuman medicinebusinessthirdSINGLE-CENTER
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